Repository logo
 

Plasmonic Sensing Assay for Long-Term Monitoring (PSALM) of Neurotransmitters in Urine.

Published version
Peer-reviewed

Repository DOI


Type

Article

Change log

Authors

Chen, Wei-Hsin 
Wang, Wenting 
Lin, Qianqi 
Grys, David-Benjamin  ORCID logo  https://orcid.org/0000-0002-4038-6388

Abstract

A liquid-based surface-enhanced Raman spectroscopy assay termed PSALM is developed for the selective sensing of neurotransmitters (NTs) with a limit of detection below the physiological range of NT concentrations in urine. This assay is formed by quick and simple nanoparticle (NP) "mix-and-measure" protocols, in which FeIII bridges NTs and gold NPs inside the sensing hotspots. Detection limits of NTs from PreNP PSALM are significantly lower than those of PostNP PSALM, when urine is pretreated by affinity separation. Optimized PSALM enables the long-term monitoring of NT variation in urine in conventional settings for the first time, allowing the development of NTs as predictive or correlative biomarkers for clinical diagnosis.

Description

Keywords

3401 Analytical Chemistry, 32 Biomedical and Clinical Sciences, 34 Chemical Sciences, Bioengineering, Nanotechnology, 4 Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies

Journal Title

ACS Nanosci Au

Conference Name

Journal ISSN

2694-2496
2694-2496

Volume Title

3

Publisher

American Chemical Society (ACS)
Sponsorship
Engineering and Physical Sciences Research Council (EP/L027151/1)
Engineering and Physical Sciences Research Council (EP/L015889/1)
Engineering and Physical Sciences Research Council (EP/R020965/1)
Relationships
Is supplemented by: