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Prospective Associations of Accelerometer-Measured Physical Activity and Sedentary Time With Incident Cardiovascular Disease, Cancer, and All-Cause Mortality.

Accepted version
Peer-reviewed

Change log

Authors

Dempsey, Paddy C 
Khaw, Kay-Tee 
Wareham, Nicholas J 
Brage, Søren 

Abstract

Insufficient moderate-to-vigorous-intensity physical activity (MVPA) and high volumes of sedentary time (ST) have both been associated with increased risk of all-cause mortality, cardiovascular disease (CVD), and some cancers1. However, epidemiological evidence has mostly relied on self-reported physical activity (PA) measures, which are prone to reporting bias and measurement error. Cohort studies incorporating objective assessments of PA are emerging2-4; but few investigate relationships of accelerometer-measured PA and ST with clinical endpoints, particularly incident CVD, and include both men and women5. Additionally, the relevance of light-intensity physical activity (LIPA) in this context, which is an important contributor to total physical activity and may be a more feasible target for middle-to-older aged adults, remains unclear. Here, we examine the prospective associations of accelerometer-measured PA and ST with incident CVD (primary outcome), incident cancer, and all-cause mortality.

Description

Keywords

aging, cardiovascular diseases, exercise, lifestyle, mortality, neoplasms, public health, sedentary behavior, Accelerometry, Adult, Aged, Cardiovascular Diseases, Exercise, Female, Humans, Male, Middle Aged, Mortality, Neoplasms, Prospective Studies, Sedentary Behavior, Survival Analysis

Journal Title

Circulation

Conference Name

Journal ISSN

0009-7322
1524-4539

Volume Title

141

Publisher

Ovid Technologies (Wolters Kluwer Health)

Rights

All rights reserved
Sponsorship
Medical Research Council (MC_UU_12015/3)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
National Health and Medical Research Council (NHMRC) (via Baker Heart and Diabetes Institute) (APP 1142685)
Medical Research Council (MC_UU_12015/1)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Medical Research Council (MR/N003284/1)
MRC (MC_UU_00006/4)
Medical Research Council (G1000143)
Medical Research Council (G0401527)
Medical Research Council (G0401527/1)
Cancer Research Uk (None)
The EPIC-Norfolk study (DOI 10.22025/2019.10.105.00004) has received funding from the Medical Research Council (MR/N003284/1 and MC-UU_12015/1) and Cancer Research UK (C864/A14136). PCD is supported by a National Health and Medical Research Council of Australia research fellowship (#1142685). PCD, TS, SB, KW and NJW are supported by the UK Medical Research Council [grant numbers MC_UU_12015/1 and MC_UU_12015/3].