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Human embryo models: the importance of national policy and governance review.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Foreman, Amy L 
Liddell, Kathleen 
Franklin, Sarah 
Jackson, Emily 
Rozeik, Christina 

Abstract

Integrated and non-integrated stem cell-based embryo models are becoming widely adopted tools in biomedical research with distinct advantages over animal models for studying human development. Although SCB-EMs have tremendous benefits for research, they raise a number of social, ethical and legal questions that affect future research and widespread adoption in industry and clinical settings. The 2021 International Society for Stem Cell Research Guidelines for Stem Cell Research and Clinical Translation provide helpful guidance on many of these issues but do not have force in domestic law. Careful appraisal and development of national legal and ethical frameworks is crucial. Paving the way to better regulation provides an ethical and social foundation to continue using human embryo models and to fully realise their potential benefits for reproductive medicine.

Description

Keywords

Animals, Humans, Biomedical Research, Embryo, Mammalian, Policy, Stem Cells

Journal Title

Curr Opin Genet Dev

Conference Name

Journal ISSN

0959-437X
1879-0380

Volume Title

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (215116/Z/18/Z)
Wellcome Trust (221856/Z/20/Z)