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The IUPHAR/BPS Guide to PHARMACOLOGY in 2024

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Armstrong, Jane F 
Faccenda, Elena 
Southan, Christopher 
Alexander, Stephen P H 

Abstract

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.guidetopharmacology.org) is an open-access, expert-curated, online database that provides succinct overviews and key references for pharmacological targets and their recommended experimental ligands. It includes over 3039 protein targets and 12 163 ligand molecules, including approved drugs, small molecules, peptides and antibodies. Here, we report recent developments to the resource and describe expansion in content over the six database releases made during the last two years. The database update section of this paper focuses on two areas relating to important global health challenges. The first, SARS-CoV-2 COVID-19, remains a major concern and we describe our efforts to expand the database to include a new family of coronavirus proteins. The second area is antimicrobial resistance, for which we have extended our coverage of antibacterials in partnership with AntibioticDB, a collaboration that has continued through support from GARDP. We discuss other areas of curation and also focus on our external links to resources such as PubChem that bring important synergies to the resources.

Description

Funder: International Union of Basic and Clinical Pharmacology; DOI: https://doi.org/10.13039/100009703


Funder: American Society for Pharmacology and Experimental Therapeutics; DOI: https://doi.org/10.13039/100005497


Funder: Laboratoires Servier; DOI: https://doi.org/10.13039/501100011725


Funder: The University of Edinburgh; DOI: https://doi.org/10.13039/501100000848

Keywords

Journal Title

Nucleic Acids Research

Conference Name

Journal ISSN

0305-1048
1362-4962

Volume Title

52

Publisher

Oxford University Press
Sponsorship
British Pharmacological Society (MED791)
GARDP (c-12440474)
Medicines for Malaria Venture (CT-5535)
Antibiotic Research UK (ANTSRG 02/2019)
Wellcome Trust (108420/Z/15/Z)