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Biomembranes in bioelectronic sensing.

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Jayaram, AK 
Pappa, AM 
Ghosh, S 
Manzer, ZA 
Traberg, WC 


Cell membranes are integral to the functioning of the cell and are therefore key to drive fundamental understanding of biological processes for downstream applications. Here, we review the current state-of-the-art with respect to biomembrane systems and electronic substrates, with a view of how the field has evolved towards creating biomimetic conditions and improving detection sensitivity. Of particular interest are conducting polymers, a class of electroactive polymers, which have the potential to create the next step-change for bioelectronics devices. Lastly, we discuss the impact these types of devices could have for biomedical applications.



bioelectronics, biomembrane sensors, label-free, membrane biophysics, supported lipid bilayers, Biomimetics, Biosensing Techniques, Cell Membrane, Electronics, Polymers

Journal Title

Trends Biotechnol

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Elsevier BV
European Research Council (337969)
Engineering and Physical Sciences Research Council (EP/L015978/1)
S.D. and R.O., acknowledge funding for this project, sponsored by the Defense Advanced Research Projects Agency (DARPA) Army Research Office and accomplished under Cooperative Agreement Number W911NF-18-2-0152. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of DARPA or the Army Research Office or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. A.K.J acknowledges funding from the Cambridge Trust, the EPSRC grant EP/L015978/1 for the Centre for Doctoral Training for Nanoscience and Nanotechnology (NanoDTC) and the Centre for Misfolding Diseases. A.M.P. acknowledges funding from the Oppenheimer Junior Research Fellowship and the Maudslay-Butler Research Fellowship at Pembroke College, Cambridge. Z.A.M. was supported by T32GM008500 from the National Institute of General Medical Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of General Medical Sciences or the National Institutes of Health. W.C.T. acknowledges funding from the Cambridge Commonwealth, European & International Trust at Cambridge University. T.P.J.K.