Repository logo
 

Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up.

Simple item page
cam.issuedOnline2020-10-23
dc.contributor.authorRikkonen, T
dc.contributor.authorSund, R
dc.contributor.authorSirola, J
dc.contributor.authorHonkanen, R
dc.contributor.authorPoole, KES
dc.contributor.authorKröger, H
dc.contributor.orcidRikkonen, T [0000-0001-5948-1222]
dc.date.accessioned2021-10-23T15:29:18Z
dc.date.available2021-10-23T15:29:18Z
dc.date.issued2021-04
dc.date.submitted2020-05-19
dc.date.updated2021-10-23T15:29:17Z
dc.descriptionFunder: Juho Vainion Säätiö; doi: http://dx.doi.org/10.13039/501100004037
dc.descriptionFunder: Pohjois-Savon Rahasto; doi: http://dx.doi.org/10.13039/501100005432
dc.descriptionFunder: Sigrid Juséliuksen Säätiö; doi: http://dx.doi.org/10.13039/501100006306
dc.description.abstractUNLABELLED: Association of body mass index and hip fracture has been controversial. In this study, women with lowest and highest body weight had the highest fracture incidence. A 25-year follow-up indicated that obesity associates with early hip fracture risk and suggested increasing trend in normal-weight women at a later stage. INTRODUCTION: Obesity is a pandemic health issue. Its association with hip fracture risk remains controversial. We studied the long-term relationship of body mass index and hip fracture incidence in postmenopausal women. METHODS: The cohort of 12,715 Finnish women born in 1932-1941 was followed for 25 years, covering ages from 58 up to 83. Fractures and deaths were obtained from national registries. Women were investigated in deciles of BMI as well as in WHO weight categories (normal, overweight, or obese). The follow-up analysis was carried out in two age strata as "early" (58-70 years) and "late" (> 70 years). Body weight information was updated accordingly. Femoral neck BMD was recorded for a subsample (n = 3163). Altogether, 427 hip fractures were observed. RESULTS: A higher risk of early hip fracture was observed in obese and normal-weight compared with overweight women with hazard ratios (HRs) of 2.3 ((95% CI) 1.4-3.7) and 2.0 (1.3-3.1) while no difference was observed in late hip fracture risk between the three WHO categories (log rank p = 0.14). All-cause mortality during the follow-up was 19.3%. Compared with normal weight women, the obese women had a higher risk of death with an HR of 1.6 (1.4-1.8) and higher baseline BMD (p < 0.001). Faster bone loss was observed in the obese compared with other women (p < 0.001). CONCLUSION: Obesity associates with earlier hip fracture and higher postfracture mortality. The obese women with low BMD have clearly the highest risk of hip fracture. This combination increases hip fracture risk more than either of the factors alone. After 75 years of age, risk appears to increase more in normal weight women, but this trend is in need of further confirmation.
dc.identifier.doi10.17863/CAM.77255
dc.identifier.eissn1433-2965
dc.identifier.issn0937-941X
dc.identifier.others00198-020-05665-w
dc.identifier.other5665
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329810
dc.languageen
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1007/s00198-020-05665-w
dc.subjectAging
dc.subjectBody mass index
dc.subjectBone mineral density
dc.subjectFollow-up study
dc.subjectGeneral population
dc.subjectHip fracture
dc.subjectMenopause
dc.subjectObesity
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBody Mass Index
dc.subjectBone Density
dc.subjectFemale
dc.subjectFinland
dc.subjectFollow-Up Studies
dc.subjectHip Fractures
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectPostmenopause
dc.subjectRisk Factors
dc.titleObesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up.
dc.typeArticle
dcterms.dateAccepted2020-10-01
prism.endingPage777
prism.issueIdentifier4
prism.publicationNameOsteoporos Int
prism.startingPage769
prism.volume32
pubs.funder-project-idSuomalainen Tiedeakatemia (310831/2017)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1007/s00198-020-05665-w

Files

Original bundle
Now showing 1 - 3 of 3
No Thumbnail Available
Name:
additional-files.zip
Size:
55.7 KB
Format:
ZIP file
Description:
Supporting information
Licence
http://creativecommons.org/licenses/by-nc/4.0/
Download
Thumbnail Image
Name:
198_2020_Article_5665.pdf
Size:
765.94 KB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
http://creativecommons.org/licenses/by-nc/4.0/
Download
No Thumbnail Available
Name:
198_2020_Article_5665_nlm.xml
Size:
83.53 KB
Format:
Extensible Markup Language
Description:
Bibliographic metadata
Licence
http://creativecommons.org/licenses/by-nc/4.0/
Download

Collections

Jisc Publications Router