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A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29.

Accepted version
Peer-reviewed

Type

Article

Change log

Abstract

In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and, in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. We assess the scope for targeting key host and viral targets in the mid-term, by first screening these targets against drugs already licensed, an agenda for drug repurposing, which should allow rapid translation to clinical trials. A simultaneous, multi-pronged approach using conventional drug discovery methods aimed at discovering novel chemical and biological means of targeting a short list of host and viral entities which should extend the arsenal of anti-SARS-CoV-2 agents. This longer term strategy would provide a deeper pool of drug choices for future-proofing against acquired drug resistance. Second, there will be further viral threats, which will inevitably evade existing vaccines. This will require a coherent therapeutic strategy which pharmacology and pharmacologists are best placed to provide. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc.

Description

Keywords

Animals, Antiviral Agents, Betacoronavirus, COVID-19, Coronavirus Infections, Drug Development, Drug Discovery, Drug Repositioning, Humans, Pandemics, Pneumonia, Viral, SARS-CoV-2, COVID-19 Drug Treatment

Journal Title

Br J Pharmacol

Conference Name

Journal ISSN

0007-1188
1476-5381

Volume Title

177

Publisher

Wiley

Rights

All rights reserved
Sponsorship
Wellcome Trust (107715/Z/15/Z)
British Heart Foundation (TG/18/4/33770)
Welcome Trust 107715/Z/15/Z