Let E be an elliptic curve defined over the rationals Q, and p be a prime at least 5 where E has multiplicative reduction. This thesis studies the Iwasawa theory of E over certain false Tate curve extensions F[infinity], with Galois group G = Gal(F[infinity]/Q). I show how the p[infinity]-Selmer group of E over F[infinity] controls the p[infinity]-Selmer rank growth within the false Tate curve extension, and how it is connected to the root numbers of E twisted by absolutely irreducible orthogonal Artin representations of G, and investigate the parity conjecture for twisted modules.