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HYPOXIA UPREGULATES PI3KINASE-DEPENDENT NEUTROPHIL DEGRANULATION AND NEUTROPHIL-MEDIATED TISSUE INJURY

Accepted version
Peer-reviewed

Type

Conference Object

Change log

Authors

Lodge, KM 
Hoenderdos, K 
Robbins, AJ 
Storisteanu, DM 
Chilvers, ER 

Abstract

Introduction:
COPD is a progressive inflammatory lung disease with multiple systemic complications, including pulmonary hypertension and cardiovascular disease (independent of smoking status). Airway neutrophilia correlates with disease severity and neutrophil elastase has been implicated in COPD pathogenesis, but precise mechanisms of tissue damage are unknown. Inflamed COPD airways are profoundly hypoxic, and this tissue hypoxia may synergise with inflammatory cytokines to promote a destructive neutrophil phenotype with enhanced potential for tissue damage.

Description

Keywords

32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, Chronic Obstructive Pulmonary Disease, Lung, Clinical Research, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Respiratory, Inflammatory and immune system

Journal Title

THORAX

Conference Name

British Thoracic Society Annual meeting

Journal ISSN

0040-6376
1468-3296

Volume Title

71

Publisher

BMJ
Sponsorship
Wellcome Trust (102706/Z/13/Z)
British Heart Foundation (None)
British Heart Foundation (PG/17/1/32532)
British Heart Foundation (PG/15/39/31519)