HYPOXIA UPREGULATES PI3KINASE-DEPENDENT NEUTROPHIL DEGRANULATION AND NEUTROPHIL-MEDIATED TISSUE INJURY
Accepted version
Peer-reviewed
Repository URI
Repository DOI
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Abstract
Introduction:
COPD is a progressive inflammatory lung disease with multiple systemic complications, including pulmonary hypertension and cardiovascular disease (independent of smoking status). Airway neutrophilia correlates with disease severity and neutrophil elastase has been implicated in COPD pathogenesis, but precise mechanisms of tissue damage are unknown. Inflamed COPD airways are profoundly hypoxic, and this tissue hypoxia may synergise with inflammatory cytokines to promote a destructive neutrophil phenotype with enhanced potential for tissue damage.
Description
Keywords
32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, Chronic Obstructive Pulmonary Disease, Lung, Clinical Research, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Respiratory, Inflammatory and immune system
Journal Title
THORAX
Conference Name
British Thoracic Society Annual meeting
Journal ISSN
0040-6376
1468-3296
1468-3296
Volume Title
71
Publisher
BMJ
Publisher DOI
Sponsorship
Wellcome Trust (102706/Z/13/Z)
British Heart Foundation (None)
British Heart Foundation (PG/17/1/32532)
British Heart Foundation (PG/15/39/31519)
British Heart Foundation (None)
British Heart Foundation (PG/17/1/32532)
British Heart Foundation (PG/15/39/31519)