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Radioproteomics in patients with ovarian cancer.

Accepted version
Peer-reviewed

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Type

Article

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Authors

McCague, Cathal 
Beer, Lucian 

Abstract

Radioproteomics is the integration of proteomics, the systematic study of the protein expression of an organism, with radiomics, the extraction and analysis of large numbers of quantitative features from medical images. This article examines this developing field, and it's application in high grade serous ovarian carcinoma. Seminal proteomic studies in the area of ovarian cancer, such as the PROVAR and CPTA studies are discussed, along side recent research, such as that highlighting the central role of methyltransferase nicotinamide N-methyltransferase as the metabolic regulation of cancer progression in the tumour stroma. Finally, this article considers a novel, hypothesis generating approach to integrate CT-based qualitative and radiomic features with proteomic analysis, and the future direction of the field. Combined advances in radiomic, proteomic and genomic analysis has the potential to signal the age of true precision medicine, where treatment is centered specifically on the molecular profile of the tumour, rather than based on empirical knowledge, thus altering the course of a disease that has the highest mortality of all cancers of the female reproductive system.

Description

Keywords

Diagnostic Imaging, Female, Humans, Image Interpretation, Computer-Assisted, Ovarian Neoplasms, Ovary, Proteomics

Journal Title

Br J Radiol

Conference Name

Journal ISSN

0007-1285
1748-880X

Volume Title

94

Publisher

Oxford University Press (OUP)