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Cellular Heterogeneity of Mesenchymal Stem/Stromal Cells in the Bone Marrow.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Mabuchi, Yo 
Okawara, Chikako 
Méndez-Ferrer, Simón  ORCID logo  https://orcid.org/0000-0002-9805-9988
Akazawa, Chihiro 

Abstract

Mesenchymal stem/stromal cells (MSCs) are present in various body tissues and help in maintaining homeostasis. The stemness of MSCs has been evaluated in vitro. In addition, analyses of cell surface antigens and gene expression patterns have shown that MSCs comprise a heterogeneous population, and the diverse and complex nature of MSCs makes it difficult to identify the specific roles in diseases. There is a lack of understanding regarding the classification of MSC properties. In this review, we explore the characteristics of heterogeneous MSC populations based on their markers and gene expression profiles. We integrated the contents of previously reported single-cell analysis data to better understand the properties of mesenchymal cell populations. In addition, the cell populations involved in the development of myeloproliferative neoplasms (MPNs) are outlined. Owing to the diversity of terms used to describe MSCs, we used the text mining technology to extract topics from MSC research articles. Recent advances in technology could improve our understanding of the diversity of MSCs and help us evaluate cell populations.

Description

Keywords

cell surface marker, heterogeneity, mesenchymal stem cells, myeloproliferative neoplasm, single-cell analysis, stem cell characterization

Journal Title

Front Cell Dev Biol

Conference Name

Journal ISSN

2296-634X
2296-634X

Volume Title

9

Publisher

Frontiers Media SA
Sponsorship
Wellcome Trust (203151/Z/16/Z)
Medical Research Council (MC_PC_17230)
MRC (MR/V005421/1)
European Research Council (648765)
Cancer Research UK (26670)