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An Indocyanine Greenā€Based Nanoprobe for In Vivo Detection of Cellular Senescence

Published version
Peer-reviewed

Repository DOI


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Authors

Baker, Andrew G 
Hartono, Muhamad 
Ou, Huiā€Ling 
Popov, Andrea Bistrović 
Brown, Emma L 

Abstract

jats:titleAbstract</jats:title>jats:pThere is an urgent need to improve conventional cancerā€treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemoā€ or radiotherapy can be used to predict the effectiveness of cancer treatment. However, although the accumulation of senescent cells is one of the hallmarks of cancer, surprisingly little progress has been made in development of strategies for their detection in vivo. To address a lack of detection tools, we developed a biocompatible, injectable organic nanoprobe (NanoJagg), which is selectively taken up by senescent cells and accumulates in the lysosomes. The NanoJagg probe is obtained by selfā€assembly of indocyanine green (ICG) dimers using a scalable manufacturing process and characterized by a unique spectral signature suitable for both photoacoustic tomography (PAT) and fluorescence imaging. In vitro, ex vivo and in vivo studies all indicate that NanoJaggs are a clinically translatable probe for detection of senescence and their PAT signal makes them suitable for longitudinal monitoring of the senescence burden in solid tumors after chemotherapy or radiotherapy.</jats:p>

Description

Publication status: Published

Keywords

32 Biomedical and Clinical Sciences, 3211 Oncology and Carcinogenesis, Cancer, Cancer

Journal Title

Angewandte Chemie

Conference Name

Journal ISSN

0044-8249
1521-3757

Volume Title

Publisher

Wiley
Sponsorship
Engineering and Physical Sciences Research Council (EP/P030467/1)
Medical Research Council (MR/R000530/1)
Engineering and Physical Sciences Research Council (EP/R003599/1)
Engineering and Physical Sciences Research Council (EP/S009000/1)
Cancer Research UK (27887)
Cancer Research UK (C62187/A29760)