Funder: We would like to acknowledge the support of the UK Biobank and the All of Us Research Program in providing access to their respective datasets. This research has been conducted using data from the UK Biobank (application number 51157) and the All of Us Research Program (by S.H. UserID 5703). Both studies have received ethical approval from their respective institutional review boards and have obtained informed consent from participants. We are grateful to the participants who generously contributed their time and data to make this research possible. This project has been funded by the Charité - Universitätsmedizin Berlin and the Einstein Foundation Berlin through the Einstein BIH Visiting Fellowship awarded to J.D. The study has been supported by the BMBF-funded Medical Informatics Initiative (HiGHmed, 01ZZ1802A - 01ZZ1802Z) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project-ID 437531118 – SFB 1470. SD is supported by a) the BHF Data Science Centre led by HDR UK (grant SP/19/3/34678), b) BigData@Heart Consortium, funded by the Innovative Medicines Initiative-2 Joint Undertaking under grant agreement 116074, c) the NIHR Biomedical Research Centre at University College London Hospital NHS Trust (UCLH BRC), d) a BHF Accelerator Award (AA/18/6/24223), e) the CVD-COVID-UK/COVID-IMPACT consortium and f) the Multimorbidity Mechanism and Therapeutic Research Collaborative (MMTRC, grant number MR/V033867/1). HH is supported by Health Data Research UK and the National Institute for Health Research, Biomedical Research Centre at University College London Hospitals.