Using prognosis to guide early detection and treatment selection in non-metastatic prostate cancer.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Gnanapragasam, Vincent J https://orcid.org/0000-0003-4722-4207
Barrett, Tristan
Massie, Charlie
Pacey, Simon
Warren, Anne
Abstract
Over recent years there has been an increasing awareness that our ideas on the lethality of primary non‐metastatic prostate cancer may need to change. This concept has emerged from a number of different sources including randomised controlled trials, reports from mature active surveillance programmes, and prognostic modelling work in large populations 1, 2. The evidence suggests that for many men without metastatic disease (85% of all presentations from the recent UK National Prostate Cancer Audit) tumours will evolve slowly and will not translate into cancer‐related mortality, at least, not within the first 10–15 years of its natural history.
Description
Keywords
Decision Support Techniques, Disease Progression, Early Detection of Cancer, Humans, Lymphatic Metastasis, Male, Patient Selection, Prognosis, Prostatic Neoplasms, Unnecessary Procedures
Journal Title
BJU Int
Conference Name
Journal ISSN
1464-4096
1464-410X
1464-410X
Volume Title
123
Publisher
Wiley
Publisher DOI
Sponsorship
Cancer Research UK (26718)
Cancer Research Uk (None)
Cancer Research Uk (None)