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Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole.

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cam.issuedOnline2018-06-19
dc.contributor.authorKadirvel, Manikandan
dc.contributor.authorCardoso, Déborah
dc.contributor.authorFreeman, Sally
dc.contributor.authorBrown, Gavin
dc.contributor.orcidBrown, Gavin [0000-0003-4443-0785]
dc.date.accessioned2018-10-10T17:30:50Z
dc.date.available2018-10-10T17:30:50Z
dc.date.issued2018
dc.description.abstractN-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70-74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.30943
dc.identifier.eissn1588-2780
dc.identifier.issn0236-5731
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283581
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1007/s10967-018-5948-4
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject11C
dc.subjectCarbamoylation
dc.subjectMethyl isocyanate
dc.subjectPET
dc.subjectRadiochemistry
dc.titleRadiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole.
dc.typeArticle
prism.endingPage984
prism.issueIdentifier2
prism.publicationDate2018
prism.publicationNameJ Radioanal Nucl Chem
prism.startingPage977
prism.volume317
rioxxterms.licenseref.startdate2018-01
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1007/s10967-018-5948-4

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