Lack of sustainable slum redevelopment guidelines in India is a policy gap that needs immediate attention. A rational design and planning route is necessary to ensure sustainability of the upcoming low-income (LIG) housing stocks. In this study, we performed a cross-sectional evaluation of LIG housing layouts through a socio-architectural and site-based wind-flow analysis route. We hypothesise that a better indoor environment in the LIG housing can be achieved through a better wind driven natural-ventilation in the living spaces, which is a function of the housing layout. Specific objectives of this study were: i) to investigate the influence of socio-architectural and geometric parameters on the LIG housing layouts; ii) to examine the effect of site-wind flow on LIG housing layouts using CFD simulations. BDD chawls of Mumbai were adopted as the case study. Results show that the current form of the LIG houses had a poor indoor environment and social interaction spaces, while the hypothesised iterated layout ‘Form A’ performed better in all the socio-architectural and wind-flow metrics that can promote relatively better quality of life. This study is a first-step approach for the development of regulatory guidelines in LIG housing design that is coherent to the context of the space.