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Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

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cam.issuedOnline2018-10-25
dc.contributor.authorLarsson, Susanna C
dc.contributor.authorTraylor, Matthew
dc.contributor.authorMarkus, Hugh S
dc.contributor.orcidLarsson, Susanna C [0000-0003-0118-0341]
dc.date.accessioned2018-12-14T00:30:39Z
dc.date.available2018-12-14T00:30:39Z
dc.date.issued2018-10-25
dc.description.abstractVitamin K plays a crucial role in blood coagulation, and hypercoagulability has been linked to atherosclerosis-related vascular disease. We used the Mendelian randomization study design to examine whether circulating vitamin K₁ (phylloquinone) levels are associated with ischemic stroke. Four single-nucleotide polymorphisms associated with vitamin K₁ levels were used as instrumental variables. Summary-level data for large artery atherosclerotic stroke (n = 4373 cases), small vessel stroke (n = 5386 cases), cardioembolic stroke (n = 7193 cases), and any ischemic stroke (n = 34,217 cases and 404,630 non-cases) were available from the MEGASTROKE consortium. Genetically-predicted circulating vitamin K₁ levels were associated with large artery atherosclerotic stroke but not with any other subtypes or ischemic stroke as a whole. The odds ratios per genetically predicted one nmol/L increase in natural log-transformed vitamin K₁ levels were 1.31 (95% confidence interval (CI) 1.12⁻1.53; p = 7.0 × 10-4) for large artery atherosclerotic stroke, 0.98 (95% CI 0.85⁻1.12; p = 0.73) for small vessel stroke, 1.01 (95% CI 0.90⁻1.14; p = 0.84) for cardioembolic stroke, and 1.05 (95% CI 0.99⁻1.11; p = 0.11) for any ischemic stroke. These findings indicate that genetic predisposition to higher circulating vitamin K₁ levels is associated with an increased risk of large artery atherosclerotic stroke.
dc.format.mediumElectronic
dc.identifier.doi10.17863/CAM.34198
dc.identifier.eissn2072-6643
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286889
dc.languageeng
dc.language.isoeng
dc.publisherMDPI AG
dc.publisher.urlhttp://dx.doi.org/10.3390/nu10111575
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMendelian randomization
dc.subjectsingle nucleotide polymorphisms
dc.subjectstroke
dc.subjectvitamin K1
dc.subjectAged
dc.subjectBrain Ischemia
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOdds Ratio
dc.subjectPolymorphism, Single Nucleotide
dc.subjectStroke
dc.subjectVitamin K 1
dc.titleCirculating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.
dc.typeArticle
dcterms.dateAccepted2018-10-23
prism.issueIdentifier11
prism.publicationDate2018
prism.publicationNameNutrients
prism.volume10
rioxxterms.licenseref.startdate2018-10-25
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3390/nu10111575

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