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The bed nucleus of the stria terminalis in threat detection: task choice and rodent experience.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Sherman, Emily R 
Thomas, Jasmine J 

Abstract

Behavioural reactivity to potential threat is used to experimentally refine models of anxiety symptoms in rodents. We present a short review of the literature tying the most commonly used tasks to model anxiety symptoms to functional recruitment of bed nucleus of the stria terminalis circuits (BNST). Using a review of studies that investigated the role of the BNST in anxiety-like behaviour in rodents, we flag the certain challenges for the field. These stem from inconsistent methods of reporting the neuroanatomical BNST subregions and the interpretations of specific behaviour across a wide variety of tasks as 'anxiety-like'. Finally, to assist in interpretation of the findings, we discuss the potential interactions between typically used 'anxiety' tasks of innate behaviour that are potentially modulated by the social and individual experience of the animal.

Description

Keywords

anxiety, bed nucleus stria terminalis, behaviour, fear, mouse, rat, Animals, Rodentia, Septal Nuclei

Journal Title

Emerg Top Life Sci

Conference Name

Journal ISSN

2397-8554
2397-8562

Volume Title

6

Publisher

Portland Press Ltd.