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Light-Regulated Molecular Trafficking in a Synthetic Water-Soluble Host.

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Del Barrio, Jesús 
Ryan, Seán TJ 
Jambrina, Pablo G 
Rosta, Edina 
Scherman, Oren A 


Cucurbit[8]uril (CB[8])-mediated complexation of a dicationic azobenzene in water allows for the light-controlled encapsulation of a variety of second guest compounds, including amino acids, dyes, and fragrance molecules. Such controlled guest sequestration inside the cavity of CB[8] enables the regulation of the thermally induced phase transition of poly(N-isopropylacrylamide)-which is not photosensitive-thus demonstrating the robustness and relevancy of the light-regulated CB[8] complexation.



Acrylamides, Acrylic Resins, Algorithms, Amino Acids, Azo Compounds, Bridged-Ring Compounds, Coloring Agents, Imidazoles, Light, Magnetic Resonance Spectroscopy, Models, Molecular, Molecular Conformation, Perfume, Polymers, Ultraviolet Rays, Water

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J Am Chem Soc

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American Chemical Society (ACS)
Engineering and Physical Sciences Research Council (EP/G060649/1)
Engineering and Physical Sciences Research Council (EP/H007024/1)
Engineering and Physical Sciences Research Council (EP/L027151/1)
European Research Council (240629)
European Commission (273807)
J.D.B. thanks Marie Curie IEF (project no. 273807). S.T.J.R. acknowledges the Cambridge Home and European Scholarship Scheme and the Robert Gardiner memorial scholarship. This work was supported by the EPSRC (reference no. EP/G060649/ 1), an ERC Starting Investigator Grant (project no. 240629), and a Next Generation Fellowship from the Walters-Kundert Foundation. The authors thank HECBioSim (EPSRC grant no. EP/L000253/1) via ARCHER, and the Ada King’s HPC3 service.