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Objective Sedentary Time, Moderate-to-Vigorous Physical Activity, and Physical Capability in a British Cohort.

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Keevil, Victoria L 
Cooper, Andrew JM 
Wareham, Nicholas J 


PURPOSE: Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time (ST) with physical functional health independent of time spent in moderate-to-vigorous physical activity (MVPA). METHODS: Community-based men and women (n = 8623, 48-92 yr old) in the European Prospective Investigation of Cancer-Norfolk study attended a health examination for objective measurement of physical capability, including grip strength (Smedley dynamometer (kg)), usual walking speed (UWS (cm·s(-1))), and timed chair stand speed (TCSS (stands per minute)). Of these, 4051 participants wore an accelerometer (GT1M ActiGraph) for 7 d to estimate time spent in MVPA (MVPA, ≥1952 counts per minute) and ST (ST, <100 counts per minute). Relations between physical capability outcomes and both MVPA and ST were explored using linear regression. The mutual independence of associations was also tested, and ST-MVPA interactions were explored using fractional polynomial models to account for nonlinear associations. RESULTS: Men in the highest compared with those in the lowest sex-specific quartile of MVPA were stronger (1.84 kg; 95% confidence interval (CI), 0.79-2.89), had faster UWS (11.7 cm·s(-1); 95% CI, 8.4-15.1) and faster TCSS (2.35 stands per minute; 95% CI, 1.11-3.59) after multivariable adjustment. Similarly, women in the highest quartile of MVPA were stronger (2.47 kg; 95% CI, 1.79-3.14) and had faster UWS (15.5 cm·s(-1); 95% CI, 12.4-18.6) and faster TCSS (3.27 stands per minute; 95% CI, 2.19-4.25). Associations persisted after further adjustment for ST. Associations between higher ST and lower physical capability were also observed, but these were attenuated after accounting for MVPA. Furthermore, no MVPA-ST interactions were observed (Pinteractions > 0.05). CONCLUSIONS: More time spent in MVPA was associated with higher physical capability, but there were no independent ST associations.



Accelerometry, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Exercise, Exercise Test, Female, Hand Strength, Humans, Male, Middle Aged, Postural Balance, Prospective Studies, Risk Factors, Sedentary Behavior, United Kingdom, Walking

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Med Sci Sports Exerc

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Ovid Technologies (Wolters Kluwer Health)
British Heart Foundation (None)
Medical Research Council (G1000143)
Medical Research Council (MC_UU_12015/3)
Wellcome Trust (092077/Z/10/Z)
Medical Research Council (MC_UU_12015/1)
Medical Research Council (G0401527)
Medical Research Council (MC_UU_12015/4)
Medical Research Council (MC_U106179471)
Cancer Research Uk (None)
Medical Research Council (MC_U106179473)
Medical Research Council (G0401527/1)
VLK declares a Wellcome Trust clinical training fellowship [092077/Z/10/Z] and KW a British Heart Foundation basic science research fellowship [FS/12/58/29709]. AJMC, NJW, and SB are supported by MRC programme grants [MC_UU_12015/3 and MC_UU_12015/4]. The EPIC-Norfolk study was supported by programme grants from the Medical Research Council [G9502233; G0401527] and Cancer Research UK [C864/A8257]. A grant from Research into Ageing [262] funded the 3HC clinic.