Repository logo
 

Single cell atlas for 11 non-model mammals, reptiles and birds.

Simple item page
cam.issuedOnline2021-12-06
dc.contributor.authorChen, Dongsheng
dc.contributor.authorSun, Jian
dc.contributor.authorZhu, Jiacheng
dc.contributor.authorDing, Xiangning
dc.contributor.authorLan, Tianming
dc.contributor.authorWang, Xiran
dc.contributor.authorWu, Weiying
dc.contributor.authorOu, Zhihua
dc.contributor.authorZhu, Linnan
dc.contributor.authorDing, Peiwen
dc.contributor.authorWang, Haoyu
dc.contributor.authorLuo, Lihua
dc.contributor.authorXiang, Rong
dc.contributor.authorWang, Xiaoling
dc.contributor.authorQiu, Jiaying
dc.contributor.authorWang, Shiyou
dc.contributor.authorLi, Haimeng
dc.contributor.authorChai, Chaochao
dc.contributor.authorLiang, Langchao
dc.contributor.authorAn, Fuyu
dc.contributor.authorZhang, Le
dc.contributor.authorHan, Lei
dc.contributor.authorZhu, Yixin
dc.contributor.authorWang, Feiyue
dc.contributor.authorYuan, Yuting
dc.contributor.authorWu, Wendi
dc.contributor.authorSun, Chengcheng
dc.contributor.authorLu, Haorong
dc.contributor.authorWu, Jihong
dc.contributor.authorSun, Xinghuai
dc.contributor.authorZhang, Shenghai
dc.contributor.authorSahu, Sunil Kumar
dc.contributor.authorLiu, Ping
dc.contributor.authorXia, Jun
dc.contributor.authorZhang, Lijing
dc.contributor.authorChen, Haixia
dc.contributor.authorFang, Dongming
dc.contributor.authorZeng, Yuying
dc.contributor.authorWu, Yiquan
dc.contributor.authorCui, Zehua
dc.contributor.authorHe, Qian
dc.contributor.authorJiang, Sanjie
dc.contributor.authorMa, Xiaoyan
dc.contributor.authorFeng, Weimin
dc.contributor.authorXu, Yan
dc.contributor.authorLi, Fang
dc.contributor.authorLiu, Zhongmin
dc.contributor.authorChen, Lei
dc.contributor.authorChen, Fang
dc.contributor.authorJin, Xin
dc.contributor.authorQiu, Wei
dc.contributor.authorWang, Tianjiao
dc.contributor.authorLi, Yang
dc.contributor.authorXing, Xiumei
dc.contributor.authorYang, Huanming
dc.contributor.authorXu, Yanchun
dc.contributor.authorHua, Yan
dc.contributor.authorLiu, Yahong
dc.contributor.authorLiu, Huan
dc.contributor.authorXu, Xun
dc.contributor.orcidDing, Peiwen [0000-0003-2905-0565]
dc.contributor.orcidWang, Shiyou [0000-0003-1901-3920]
dc.contributor.orcidSahu, Sunil Kumar [0000-0002-4742-9870]
dc.contributor.orcidJin, Xin [0000-0001-7554-4975]
dc.contributor.orcidLiu, Huan [0000-0003-3909-0931]
dc.contributor.orcidXu, Xun [0000-0002-5338-5173]
dc.date.accessioned2021-12-24T13:35:59Z
dc.date.available2021-12-24T13:35:59Z
dc.date.issued2021-12-06
dc.date.submitted2020-11-09
dc.date.updated2021-12-24T13:35:53Z
dc.description.abstractThe availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the expression patterns of viral entry genes in different hosts. However, such exploration for SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing for 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat and rabbit), poultry (duck and pigeon), and wildlife (pangolin, tiger, and deer), and investigated the co-expression of ACE2 and TMPRSS2. Furthermore, cross-species analysis of the lung cell atlas of the studied mammals, reptiles, and birds reveals core developmental programs, critical connectomes, and conserved regulatory circuits among these evolutionarily distant species. Overall, our work provides a compendium of gene expression profiles for non-model animals, which could be employed to identify potential SARS-CoV-2 target cells and putative zoonotic reservoirs.
dc.identifier.doi10.17863/CAM.79238
dc.identifier.eissn2041-1723
dc.identifier.issn2041-1723
dc.identifier.others41467-021-27162-2
dc.identifier.other27162
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331789
dc.languageen
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41467-021-27162-2
dc.subjectAngiotensin-Converting Enzyme 2
dc.subjectAnimals
dc.subjectAtlases as Topic
dc.subjectBirds
dc.subjectCell Communication
dc.subjectEvolution, Molecular
dc.subjectGene Regulatory Networks
dc.subjectHost-Pathogen Interactions
dc.subjectLung
dc.subjectMammals
dc.subjectReceptors, Virus
dc.subjectReptiles
dc.subjectSARS-CoV-2
dc.subjectSerine Endopeptidases
dc.subjectSingle-Cell Analysis
dc.subjectTranscriptome
dc.subjectViral Tropism
dc.subjectVirus Internalization
dc.titleSingle cell atlas for 11 non-model mammals, reptiles and birds.
dc.typeArticle
dcterms.dateAccepted2021-09-18
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume12
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41467-021-27162-2

Files

Original bundle
Now showing 1 - 5 of 6
Thumbnail Image
Name:
41467_2021_27162_MOESM3_ESM.pdf
Size:
85.56 KB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
http://creativecommons.org/licenses/by/4.0/
Download
No Thumbnail Available
Name:
41467_2021_Article_27162_nlm.xml
Size:
169.61 KB
Format:
Extensible Markup Language
Description:
Bibliographic metadata
Licence
http://creativecommons.org/licenses/by/4.0/
Download
No Thumbnail Available
Name:
additional-files.zip
Size:
298.72 MB
Format:
ZIP file
Description:
Supporting information
Licence
http://creativecommons.org/licenses/by/4.0/
Download
Thumbnail Image
Name:
41467_2021_27162_MOESM1_ESM.pdf
Size:
552.51 KB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
http://creativecommons.org/licenses/by/4.0/
Download
Thumbnail Image
Name:
41467_2021_Article_27162.pdf
Size:
15.05 MB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
http://creativecommons.org/licenses/by/4.0/
Download

Collections

Jisc Publications Router