Repository logo
 

Interpreting vibrational circular dichroism spectra: the Cai•factor for absolute configuration with confidence

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Lewis, Richard J 
Lam, Jonathan 

Abstract

Vibrational circular dichroism (VCD) spectroscopy can generate the data required for the assignment of absolute configuration, but the spectra are hard to interpret. We have recorded VCD data for thirty pairs of small organic compounds and we use this database to validate a method for the automated analysis of VCD spectra and the assignment of absolute configuration: the Cai•factor (Configuration: absolute information). The analysis of the data demonstrates that the procedure is a reliable and time-efficient method for determination of absolute configuration, which gives both the assignment and a measure of confidence in the outcome, even when the spectra are imperfect. The majority of molecules tested have a high confidence score and all of these have the correct assignment.

Description

Keywords

Journal Title

Journal of Cheminformatics

Conference Name

Journal ISSN

1758-2946

Volume Title

Publisher

BioMed Central
Sponsorship
AstraZeneca
Relationships
Is previous version of: