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Segregation and integration of the functional connectome in neurodevelopmentally 'at risk' children.

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cam.issuedOnline2021-12-15
dc.contributor.authorJones, Jonathan S
dc.contributor.authorCALM Team
dc.contributor.authorAstle, Duncan E
dc.contributor.orcidAstle, Duncan [0000-0002-7042-5392]
dc.date.accessioned2022-01-05T10:46:10Z
dc.date.available2022-01-05T10:46:10Z
dc.date.issued2022-05
dc.date.submitted2021-05-10
dc.date.updated2022-01-05T10:46:09Z
dc.description.abstractFunctional connectivity within and between Intrinsic Connectivity Networks (ICNs) transforms over development and is thought to support high order cognitive functions. But how variable is this process, and does it diverge with altered cognitive development? We investigated age-related changes in integration and segregation within and between ICNs in neurodevelopmentally 'at-risk' children, identified by practitioners as experiencing cognitive difficulties in attention, learning, language, or memory. In our analysis we used performance on a battery of 10 cognitive tasks alongside resting-state functional magnetic resonance imaging in 175 at-risk children and 62 comparison children aged 5-16. We observed significant age-by-group interactions in functional connectivity between two network pairs. Integration between the ventral attention and visual networks and segregation of the limbic and fronto-parietal networks increased with age in our comparison sample, relative to at-risk children. Furthermore, functional connectivity between the ventral attention and visual networks in comparison children significantly mediated age-related improvements in executive function, compared to at-risk children. We conclude that integration between ICNs show divergent neurodevelopmental trends in the broad population of children experiencing cognitive difficulties, and that these differences in functional brain organisation may partly explain the pervasive cognitive difficulties within this group over childhood and adolescence.
dc.identifier.doi10.17863/CAM.79434
dc.identifier.eissn1467-7687
dc.identifier.issn1363-755X
dc.identifier.otherdesc13209
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331986
dc.languageen
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1111/desc.13209
dc.subjectcognitive development
dc.subjectexecutive function
dc.subjectfMRI
dc.subjectfunctional connectivity
dc.subjectintrinsic connectivity networks
dc.subjectneurodevelopment
dc.subjectAdolescent
dc.subjectBrain
dc.subjectChild
dc.subjectConnectome
dc.subjectExecutive Function
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectNerve Net
dc.titleSegregation and integration of the functional connectome in neurodevelopmentally 'at risk' children.
dc.typeArticle
dcterms.dateAccepted2021-11-22
prism.publicationNameDev Sci
pubs.funder-project-idMedical Research Council (MC_UU_00005/16)
pubs.funder-project-idMedical Research Council (MC_UU_00005/10)
pubs.funder-project-idMedical Research Council (MC_UU_00005/2)
pubs.funder-project-idMedical Research Council (MC_U105559837)
pubs.funder-project-idMRC (MC_UU_00030/11)
pubs.funder-project-idMRC (MC_UU_00030/2)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1111/desc.13209

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