Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex- dependent manner

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Pantaleão, Lucas C 
Inzani, Isabella 
Furse, Samuel 
Loche, Elena 
Hufnagel, Antonia 

Maternal obesity during pregnancy has immediate and long-term detrimental effects on the offspring heart. In this study, we characterized the cardiac and circulatory lipid profiles in late gestation E18.5 fetuses of diet-induced obese pregnant mice and established the changes in lipid abundance and fetal cardiac transcriptomics. We used untargeted and targeted lipidomics and transcriptomics to define changes in the serum and cardiac lipid composition and fatty acid metabolism in male and female fetuses. From these analyses we observed: (1) maternal obesity affects the maternal and fetal serum lipidome distinctly; (2) female fetal heart lipidomes are more sensitive to maternal obesity than males; (3) changes in lipid supply might contribute to early expression of lipolytic genes in mouse hearts exposed to maternal obesity. These results highlight the existence of sexually dimorphic responses of the fetal heart to the same in utero obesogenic environment and identify lipids species that might mediate programming of cardiovascular health.

Research Article, Biochemistry and Chemical Biology, Developmental Biology, maternal obesity, fetal heart, heart metabolism, lipidomics, transcriptomics, Mouse
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eLife Sciences Publications Ltd
British Heart Foundation (RG/17/12/33167)
Wellcome Trust (208363/Z/17/Z)
Biotechnology and Biological Sciences Research Council (BB/M027252/1)
MRC (MC_UU_00014/4)
MRC Metabolic Diseases Unit [MRC_MC_UU_00014/4] Cambridge Home and EU Student Scholarship British Heart Foundation studentship [FS/12/64/30001] II was supported by a British Heart Foundation studentship [FS/18/56/35177]