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Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Branche, Angela R 
Falsey, Ann R 
Losada, Cecilia 

Abstract

We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.

Description

Keywords

SARS-CoV-2, vaccine, variant, Adult, Humans, Vaccines, Combined, 2019-nCoV Vaccine mRNA-1273, Clinical Protocols, RNA, Messenger

Journal Title

J Infect Dis

Conference Name

Journal ISSN

0022-1899
1537-6613

Volume Title

Publisher

Oxford University Press (OUP)
Sponsorship
National Institute of Allergy and Infectious Diseases (R01AI165818)
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (0258-B504-4612)
National Institutes of Health (NIH) (1R01AI165818-01)