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Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.

Accepted version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/355837

Repository DOI

https://doi.org/10.17863/CAM.100680
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Primary Accepted version (926.04 KB)

Type

Article

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Authors

Rouphael, Nadine G  ORCID logo  https://orcid.org/0000-0002-2512-7919
Diemert, David J  ORCID logo  https://orcid.org/0000-0002-2789-0512

Abstract

We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.

Description

Keywords

SARS-CoV-2, vaccine, variant, Adult, Humans, Vaccines, Combined, 2019-nCoV Vaccine mRNA-1273, Clinical Protocols, RNA, Messenger

Journal Title

J Infect Dis

Conference Name

Journal ISSN

0022-1899
1537-6613

Volume Title

Publisher

Oxford University Press (OUP)

Publisher DOI

https://doi.org/10.1093/infdis/jiad323

Rights and licensing

All rights reserved
Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
National Institute of Allergy and Infectious Diseases (R01AI165818)
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (0258-B504-4612)
National Institutes of Health (NIH) (1R01AI165818-01)

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University of Cambridge Research Outputs (Articles and Conferences)