Repository logo
 

Maternal obesity and ovarian failure: is leptin the culprit?

Published version
Peer-reviewed

Type

Article

Change log

Authors

Galvão, António Miguel  ORCID logo  https://orcid.org/0000-0002-7990-3071

Abstract

At the time of its discovery and characterization in 1994, leptin was mostly considered a metabolic hormone able to regulate body weight and energy homeostasis. However, in recent years, a great deal of literature has revealed leptin's pleiotropic nature, through its involvement in numerous physiological contexts including the regulation of the female reproductive tract and ovarian function. Obesity has been largely associated with infertility, and leptin signalling is known to be dysregulated in the ovaries of obese females. Hence, the disruption of ovarian leptin signalling was shown to contribute to the pathophysiology of ovarian failure in obese females, affecting transcriptional programmes in the gamete and somatic cells. This review attempts to uncover the underlying mechanisms contributing to female infertility associated with obesity, as well as to shed light on the role of leptin in the metabolic dysregulation within the follicle, the effects on the oocyte epigenome, and the potential long-term consequence to embryo programming.

Description

Keywords

epigenetics, leptin, maternal obesity, oocyte quality, ovarian leptin resistance

Journal Title

Anim Reprod

Conference Name

Journal ISSN

1806-9614
1984-3143

Volume Title

19

Publisher

FapUNIFESP (SciELO)