Repository logo

The trans-omics landscape of COVID-19

Published version

Change log


Wu, Peng 
Chen, Dongsheng 
Ding, Wencheng 
Wu, Ping 
Hou, Hongyan 


Abstract: The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.



Article, /631/250/2499, /631/250/2502, /631/250/255/2514, /631/553/1833, /38/91, /38/43, /38/23, article

Journal Title

Nature Communications

Conference Name

Journal ISSN


Volume Title



Nature Publishing Group UK