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The neuropeptidergic connectome of C. elegans.

Published version
Peer-reviewed

Repository DOI


Type

Article

Change log

Authors

Ripoll-Sánchez, Lidia 
Watteyne, Jan 
Sun, HaoSheng 
Fernandez, Robert 
Taylor, Seth R 

Abstract

Efforts are ongoing to map synaptic wiring diagrams, or connectomes, to understand the neural basis of brain function. However, chemical synapses represent only one type of functionally important neuronal connection; in particular, extrasynaptic, "wireless" signaling by neuropeptides is widespread and plays essential roles in all nervous systems. By integrating single-cell anatomical and gene-expression datasets with biochemical analysis of receptor-ligand interactions, we have generated a draft connectome of neuropeptide signaling in the C. elegans nervous system. This network is characterized by high connection density, extended signaling cascades, autocrine foci, and a decentralized topology, with a large, highly interconnected core containing three constituent communities sharing similar patterns of input connectivity. Intriguingly, several key network hubs are little-studied neurons that appear specialized for peptidergic neuromodulation. We anticipate that the C. elegans neuropeptidergic connectome will serve as a prototype to understand how networks of neuromodulatory signaling are organized.

Description

Keywords

C. elegans, connectomics, networks, neuromodulation, neuropeptides, Animals, Connectome, Caenorhabditis elegans, Neurons, Gene Expression, Synapses

Journal Title

Neuron

Conference Name

Journal ISSN

0896-6273
1097-4199

Volume Title

111

Publisher

Elsevier BV
Sponsorship
National Institute for Health and Care Research (IS-BRC-1215-20014)