Association Between Bacterial Homoplastic Variants and Radiological Pathology in Tuberculosis
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Abstract
- What is the key question? Is there an association between bacterial genotype and pathology in drug resistant tuberculosis?
- What is the bottom line? This study demonstrates that polymorphisms in Rv2828c and rpoC are independently associated with more widespread pathology on the pre-treatment chest radiograph of drug-resistant tuberculosis patients.
- Why read on? As the first study to compare the M. tuberculosis genome to radiological pathology on the chest radiograph, it improves our understanding of how pathogen genetic factors contribute to pathology in tuberculosis which could enable tailored treatments to the most pathogenic and infectious strains.
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0040-6376
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BMJ
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Except where otherwised noted, this item's license is described as Attribution 4.0 International
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Wellcome Trust (098600/Z/12/Z)
This work was supported by the Wellcome Trust (Grant Number 201470/Z/16/Z). JM acknowledges the EU FP7-PEOPLE-2013-IRSES-Marie Curie Action DEANN “International Research Staff Exchange Scheme” (19061), which covered the costs for a 3-month visit to London to work with LG. FB acknowledges support from the BBSRC GCRF scheme and the National Institute for Health Research University College London Hospitals Biomedical Research Centre. SP acknowledges funding by the Health Innovation Challenge Fund (WT098600, HICF-T5-342), a parallel funding partnership between the Department of Health and Wellcome Trust.