Organoid systems to study the human female reproductive tract and pregnancy
Abstract: Both the proper functioning of the female reproductive tract (FRT) and normal placental development are essential for women’s health, wellbeing, and pregnancy outcome. The study of the FRT in humans has been challenging due to limitations in the in vitro and in vivo tools available. Recent developments in 3D organoid technology that model the different regions of the FRT include organoids of the ovaries, fallopian tubes, endometrium and cervix, as well as placental trophoblast. These models are opening up new avenues to investigate the normal biology and pathology of the FRT. In this review, we discuss the advances, potential, and limitations of organoid cultures of the human FRT.
Funder: Centre for Trophoblast Research L'Oreal Women in Science Fellowship
Isaac Newton Trust (G100391)
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) (853546)
King Saud University (KSU) (KSU1520)
Wellcome Trust (Wellcome) (UNS13724)