Homeostatic role of B-1 cells in tissue immunity.

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Suchanek, Ondrej 
Clatworthy, Menna R 

To date, studies of tissue-resident immunity have mainly focused on innate immune cells and T cells, with limited data on B cells. B-1 B cells are a unique subset of B cells with innate-like properties, enriched in murine pleural and peritoneal cavities and distinct from conventional B-2 cells in their ontogeny, phenotype and function. Here we discuss how B-1 cells represent exemplar tissue-resident immune cells, summarizing the evidence for their long-term persistence & self-renewal within tissues, differential transcriptional programming shaped by organ-specific environmental cues, as well as their tissue-homeostatic functions. Finally, we review the emerging data supporting the presence and homeostatic role of B-1 cells across non-lymphoid organs (NLOs) both in mouse and human.


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B-1 cells, homeostasis, innate-like B cells, non-lymphoid organ, tissue immunity, tissue-residency, Humans, Animals, Mice, B-Lymphocyte Subsets, B-Lymphocytes, Cues, Homeostasis, Peritoneal Cavity
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Front Immunol
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Frontiers Media SA