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Spatial Distribution and Hierarchical Clustering of β-Amyloid and Glucose Metabolism in Alzheimer's Disease.

cam.issuedOnline2022-06-06
dc.contributor.authorZhou, Da-An
dc.contributor.authorXu, Kai
dc.contributor.authorZhao, Xiaobin
dc.contributor.authorChen, Qian
dc.contributor.authorSang, Feng
dc.contributor.authorFan, Di
dc.contributor.authorSu, Li
dc.contributor.authorZhang, Zhanjun
dc.contributor.authorAi, Lin
dc.contributor.authorChen, Yaojing
dc.date.accessioned2022-06-29T19:42:24Z
dc.date.available2022-06-29T19:42:24Z
dc.date.issued2022
dc.date.submitted2021-10-02
dc.date.updated2022-06-29T19:42:24Z
dc.description.abstractIncreased amyloid burden and decreased glucose metabolism are important characteristics of Alzheimer's disease (AD), but their spatial distribution and hierarchical clustering organization are still poorly understood. In this study, we explored the distribution and clustering organization of amyloid and glucose metabolism based on 18F-florbetapir and 18F-fluorodeoxyglucose PET data from 68 AD patients and 20 cognitively normal individuals. We found that: (i) cortical regions with highest florbetapir binding were the regions with high glucose metabolism; (ii) the percentage changes of amyloid deposition were greatest in the frontal and temporal areas, and the hypometabolism was greatest in the parietal and temporal areas; (iii) brain areas can be divided into three hierarchical clusters by amyloid and into five clusters by metabolism using a hierarchical clustering approach, indicating that adjacent regions are more likely to be grouped into one sub-network; and (iv) there was a significant positive correlation in any pair of amyloid-amyloid and metabolism-metabolism sub-networks, and a significant negative correlation in amyloid-metabolism sub-networks. This may suggest that the influence forms and brain regions of AD on different pathological markers may not be synchronous, but they are closely related.
dc.identifier.doi10.17863/CAM.85848
dc.identifier.eissn1663-4365
dc.identifier.issn1663-4365
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338435
dc.languageen
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.publisher.urlhttp://dx.doi.org/10.3389/fnagi.2022.788567
dc.subjectAlzheimer’s Disease
dc.subjectglucose metabolism
dc.subjecthierarchical organization
dc.subjectspatial distribution
dc.subjectβ-amyloid
dc.titleSpatial Distribution and Hierarchical Clustering of β-Amyloid and Glucose Metabolism in Alzheimer's Disease.
dc.typeArticle
dcterms.dateAccepted2022-05-09
prism.publicationNameFront Aging Neurosci
prism.volume14
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3389/fnagi.2022.788567

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