Mechanical Characterization of Human Brain Tissue and Soft Dynamic Gels Exhibiting Electromechanical Neuro-Mimicry


Type
Article
Change log
Authors
Scherman, Oren 
Tabet, Anthony 
Vigil, Julian 
Hallou, Clement 
Abstract

Synthetic hydrogels are an important class of materialsin tissue engineering, drug delivery, and other biomedicalfields. Their mechanical and electrical properties can betuned to match those of biological tissues. In this work,we report on hydrogels that exhibit both mechanical andelectrical biomimicry. The presented dual networks consistof supramolecular networks formed from 2:1 homoternarycomplexes of imidazolium-based guest molecules in cucu-bit[8]uril and covalent networks of oligoethylene glycol-(di)methacrylate. We also investigate the viscoelastic prop-erties of human brain tissues. The mechanical properties ofthe dual network gels are benchmarked against the humantissue, and we find that they both are neuro-mimetic and ex-hibit cytocompatiblity in a neural stem cell model.

Description
Keywords
biomaterials, human tissue rheology, neuro-mimicry, soft electronics, supramolecular gels, Biomimetic Materials, Brain, Bridged-Ring Compounds, Elasticity, Electric Conductivity, Humans, Hydrogels, Imidazoles, Polyethylene Glycols, Rheology, Shear Strength, Tissue Engineering
Journal Title
Advanced Healthcare Materials
Conference Name
Journal ISSN
2192-2640
2192-2659
Volume Title
8
Publisher
Wiley
Sponsorship
Royal Society (NF170062)
Winston Churchill Foundation of the United States. The Newton International Fellowship.