Light-Field Microscopy for Optical Imaging of Neuronal Activity: When Model-Based Methods Meet Data-Driven Approaches.


Type
Article
Change log
Authors
Jadan, Herman Verinaz 
Howe, Carmel L 
Foust, Amanda J 
Dragotti, Pier Luigi 
Abstract

Understanding how networks of neurons process information is one of the key challenges in modern neuroscience. A necessary step to achieve this goal is to be able to observe the dynamics of large populations of neurons over a large area of the brain. Light-field microscopy (LFM), a type of scanless microscope, is a particularly attractive candidate for high-speed three-dimensional (3D) imaging. It captures volumetric information in a single snapshot, allowing volumetric imaging at video frame-rates. Specific features of imaging neuronal activity using LFM call for the development of novel machine learning approaches that fully exploit priors embedded in physics and optics models. Signal processing theory and wave-optics theory could play a key role in filling this gap, and contribute to novel computational methods with enhanced interpretability and generalization by integrating model-driven and data-driven approaches. This paper is devoted to a comprehensive survey to state-of-the-art of computational methods for LFM, with a focus on model-based and data-driven approaches.

Description
Keywords
Deep learning, Light-field microscopy, Neuroimaging, model-driven and data-driven approaches
Journal Title
IEEE Signal Process Mag
Conference Name
Journal ISSN
1053-5888
1558-0792
Volume Title
39
Publisher
Institute of Electrical and Electronics Engineers (IEEE)