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Trans-acting translational regulatory RNA binding proteins.

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cam.issuedOnline2018-01-17
dc.contributor.authorHarvey, Robert F
dc.contributor.authorSmith, Tom S
dc.contributor.authorMulroney, Thomas
dc.contributor.authorQueiroz, Rayner ML
dc.contributor.authorPizzinga, Mariavittoria
dc.contributor.authorDezi, Veronica
dc.contributor.authorVillenueva, Eneko
dc.contributor.authorRamakrishna, Manasa
dc.contributor.authorLilley, Kathryn S
dc.contributor.authorWillis, Anne E
dc.contributor.orcidSmith, Tom [0000-0002-0697-8777]
dc.contributor.orcidLilley, Kathryn [0000-0003-0594-6543]
dc.contributor.orcidWillis, Anne [0000-0002-1470-8531]
dc.date.accessioned2018-06-25T13:33:14Z
dc.date.available2018-06-25T13:33:14Z
dc.date.issued2018-05
dc.description.abstractThe canonical molecular machinery required for global mRNA translation and its control has been well defined, with distinct sets of proteins involved in the processes of translation initiation, elongation and termination. Additionally, noncanonical, trans-acting regulatory RNA-binding proteins (RBPs) are necessary to provide mRNA-specific translation, and these interact with 5' and 3' untranslated regions and coding regions of mRNA to regulate ribosome recruitment and transit. Recently it has also been demonstrated that trans-acting ribosomal proteins direct the translation of specific mRNAs. Importantly, it has been shown that subsets of RBPs often work in concert, forming distinct regulatory complexes upon different cellular perturbation, creating an RBP combinatorial code, which through the translation of specific subsets of mRNAs, dictate cell fate. With the development of new methodologies, a plethora of novel RNA binding proteins have recently been identified, although the function of many of these proteins within mRNA translation is unknown. In this review we will discuss these methodologies and their shortcomings when applied to the study of translation, which need to be addressed to enable a better understanding of trans-acting translational regulatory proteins. Moreover, we discuss the protein domains that are responsible for RNA binding as well as the RNA motifs to which they bind, and the role of trans-acting ribosomal proteins in directing the translation of specific mRNAs. This article is categorized under: RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes Translation > Translation Regulation Translation > Translation Mechanisms.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.24792
dc.identifier.eissn1757-7012
dc.identifier.issn1757-7004
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/277474
dc.languageeng
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1002/wrna.1465
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectIRES uORF
dc.subjectRNA binding protein
dc.subjectinteractome capture
dc.subjectmRNA translation
dc.subjectprotein synthesis
dc.subjectterminal oligopyrimidine tract
dc.subjectAnimals
dc.subjectHumans
dc.subjectProtein Biosynthesis
dc.subjectProtein Domains
dc.subjectRNA-Binding Proteins
dc.titleTrans-acting translational regulatory RNA binding proteins.
dc.typeArticle
dcterms.dateAccepted2017-12-04
prism.issueIdentifier3
prism.publicationDate2018
prism.publicationNameWiley Interdiscip Rev RNA
prism.startingPagee1465
prism.volume9
pubs.funder-project-idWellcome Trust (110170/Z/15/Z)
pubs.funder-project-idWellcome Trust (110071/Z/15/Z)
rioxxterms.licenseref.startdate2018-05
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1002/wrna.1465

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