The aim of this research is to provide a comprehensive decision-making process and a framework for exploring configuration opportunities for commercially viable supply chains (SCs) arising from renewable chemical feedstocks (RCFs), towards delivering value-added intermediates or end-products. To that end, we first introduce an inclusive hierarchical decision-making process that applies to all stakeholders involved in the design and management of circular SCs defined by RCF platform technologies. Thereafter, the identified decisions are encapsulated in a framework highlighting that the potential SC configuration alternatives are grounded on four essential theme areas, namely: (i) renewable chemical feedstock, (ii) technology, (iii) market, and (iv) value and viability. Our analysis highlights the significance of RCFs due to their emerging potential of replacing petrochemicals; however, existing research is evidently limited due to scope and data related challenges, and the inherent complexity at the market side of the respective supply networks.