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Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

Published version
Peer-reviewed

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Authors

Huhn, Oisín 
Ivarsson, Martin A. 
Gardner, Lucy 
Hollinshead, Mike 
Stinchcombe, Jane C 

Abstract

Abstract: During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass cytometry, we characterise five main dILC subsets: decidual NK cells (dNK)1–3, ILC3s and proliferating NK cells. Following stimulation, dNK2 and dNK3 produce more chemokines than dNK1 including XCL1 which can act on both maternal dendritic cells and fetal EVT. In contrast, dNK1 express receptors including Killer-cell Immunoglobulin-like Receptors (KIR), indicating they respond to HLA class I ligands on EVT. Decidual NK have distinctive organisation and content of granules compared with peripheral blood NK cells. Acquisition of KIR correlates with higher granzyme B levels and increased chemokine production in response to KIR activation, suggesting a link between increased granule content and dNK1 responsiveness. Our analysis shows that dILCs are unique and provide specialised functions dedicated to achieving placental development and successful reproduction.

Description

Keywords

Article, /631/136/3194, /631/250/2504/2506, /631/443/494, /13/31, /13/21, /49/1, article

Journal Title

Nature Communications

Conference Name

Journal ISSN

2041-1723

Volume Title

11

Publisher

Nature Publishing Group UK
Sponsorship
Wellcome Trust (Wellcome) (200841/Z/16/Z)
RCUK | MRC | Medical Research Foundation (MR/P001092/1)