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RLS and blood donation.

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cam.issuedOnline2009-01-20
dc.contributor.authorBurchell, Brendan J
dc.contributor.authorAllen, Richard P
dc.contributor.authorMiller, Jessica K
dc.contributor.authorHening, Wayne A
dc.contributor.authorEarley, Christopher J
dc.contributor.orcidBurchell, Brendan [0000-0002-8243-937X]
dc.date.accessioned2012-04-15T20:59:22Z
dc.date.available2012-04-15T20:59:22Z
dc.date.issued2009-09
dc.description.abstractBACKGROUND AND PURPOSE: The link between brain iron deficiency and RLS is now well established. In a related observation, several conditions that can deplete iron stores have been linked to increased probability of RLS. Blood donation has been linked to iron deficiency. It has thus been hypothesized that donating blood may be a risk factor for developing RLS. PATIENTS AND METHODS: Two thousand and five UK blood donors, ranging from first-time donors to some who had donated more than 70 times, completed the validated Cambridge-Hopkins RLS questionnaire (CH-RLSq) following their donation session. The questionnaire included a set of questions designed to diagnose RLS. The donors' histories of blood donations were determined both from self-report and from the National Blood Service database. RESULTS: A number of statistical models were constructed to determine whether the probability of RLS diagnosis was related to the history of blood donations. Controlling for age and sex, no evidence was found to suggest that a greater number or frequency of blood donations increased the risk of RLS. Even amongst sub-groups especially vulnerable to iron depletion through blood donation, such as vegetarians or low weight individuals, no evidence for an increased risk of RLS could be found. CONCLUSIONS: We found no evidence that the frequency or number of blood donations up to the UK maximum of three times a year would increase the risk of RLS.
dc.identifier.citationBurchell, Brendan J., Richard P. Allen, Jessica K. Miller, Wayne A. Hening, and Christopher J. Earley. "RLS and blood donation" Sleep Medicine 10(8) (2009): 844-849.
dc.identifier.eissn1878-5506
dc.identifier.issn1389-9457
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/242166
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier BV
dc.publisher.urlhttp://dx.doi.org/10.1016/j.sleep.2008.09.013
dc.relation.ispartofseries10(8),
dc.subjectAdult
dc.subjectAnemia, Iron-Deficiency
dc.subjectBlood Donors
dc.subjectBody Mass Index
dc.subjectDatabases, Factual
dc.subjectDiet, Vegetarian
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectRestless Legs Syndrome
dc.subjectRisk Factors
dc.subjectUnited Kingdom
dc.titleRLS and blood donation.
dc.typeArticle
dcterms.dateAccepted2008-09-16
prism.publicationDate2009
prism.publicationNameSleep Med
rioxxterms.licenseref.startdate2009
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionofrecord10.1016/j.sleep.2008.09.013

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