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Research Data supporting "Characterizing collagen scaffold compliance with native myocardial strains using an ex-vivo cardiac model: the physio-mechanical influence of scaffold architecture and attachment method"


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Authors

Cyr, Jamie A 
Burdett, Clare 
Pürstl, Julia T 
Thompson, Robert P 
Troughton, Samuel C 

Description

Description of Data for Characterizing Scaffold Compliance to Native Myocardial Strains This zip folder contains the raw data used in the publication ‘Characterizing collagen scaffold compliance with native myocardial strains using an ex-vivo cardiac model: the physio- mechanical influence of scaffold architecture and attachment method.’ Alignment and pore size data were measured using X-ray micro-computed tomography (µCT) images (Skyscan 1172). µCT images were taken of each scaffold with a voltage of 25 kV, current of 138 mA, and a pixel size of 5.46 µm. Reconstructions of mCT images were performed with NRecon software by Skyscan and analysed in ImageJ. Results for scaffold alignment (.txt files) and scaffold pore size (.txt files) are included in the zip file. Video samples of each conditions (aligned suture, aligned glue, isotropic suture, isotropic glue) were recorded with a GoPro Hero 5 camera at 30 fps. Video files (.mp4 files) ) are also included in the zip file.

Version

Software / Usage instructions

MP4 files, .xls

Keywords

2D strain, Cardiac patch, Collagen scaffold, Epicardial deformation, Ice templating, Regenerative cardiac tissue

Publisher

Sponsorship
Engineering and Physical Sciences Research Council (EP/N019938/1)
British Heart Foundation (SP/15/7/31561)
This work was supported by the British Heart Foundation Oxbridge Centre for Regenerative Medicine RM/17/2/33380. J.A.C. was supported by the Gates Cambridge Fellowship. C.B. was supported by the Wellcome Trust and the Wellcome Clinicians Fellow Program. S.S. was supported by a British Heart Foundation Senior Fellowship [Grant FS/18/46/33663] and the British Heart Foundation Centre for Cardiovascular Research Excellence [ Grant RE/18/1/34212]. S.M.B. and R.E.C. were supported by EPSRC Established Career Fellowship EP/N019938/1 and the British Heart Foundation [Grants NH/11/1/28922, RG/15/4/31268 and SP/15/7/31561]. We also acknowledge core support from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute. This research was funded in whole, or in part, by the Wellcome Trust [Grant Number: 203151/Z/16/Z]. For the purpose of Open Access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission.
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