The use of large animals to facilitate the process of MSC going from laboratory to patient—‘bench to bedside’


Change log
Authors
Hotham, W. E. 
Henson, F. M. D. 
Abstract

Abstract: Large animal models have been widely used to facilitate the translation of mesenchymal stem cells (MSC) from the laboratory to patient. MSC, with their multi-potent capacity, have been proposed to have therapeutic benefits in a number of pathological conditions. Laboratory studies allow the investigation of cellular and molecular interactions, while small animal models allow initial ‘proof of concept’ experiments. Large animals (dogs, pigs, sheep, goats and horses) are more similar physiologically and structurally to man. These models have allowed clinically relevant assessments of safety, efficacy and dosing of different MSC sources prior to clinical trials. In this review, we recapitulate the use of large animal models to facilitate the use of MSC to treat myocardial infarction—an example of one large animal model being considered the ‘gold standard’ for research and osteoarthritis—an example of the complexities of using different large animal models in a multifactorial disease. These examples show how large animals can provide a research platform that can be used to evaluate the value of cell-based therapies and facilitate the process of ‘bench to bedside’.

Description
Keywords
Original Article, Mesenchymal stem cell, Large animal, Osteoarthritis, Myocardial infarction
Journal Title
Cell Biology and Toxicology
Conference Name
Journal ISSN
0742-2091
1573-6822
Volume Title
36
Publisher
Springer Netherlands
Sponsorship
Horizon 2020 (761214)