Genetically Predicted Lipid Traits, Diabetes Liability, and Carotid Intima-Media Thickness in African Ancestry Individuals: A Mendelian Randomization Study.
Carotid intima-media thickness (cIMT) is a measure of atherosclerosis used to predict cardiovascular disease.1 Lipid traits and type 2 diabetes (T2D) have been implicated in the pathogenesis of cIMT. Statins, which reduce low-density lipoprotein cholesterol (LDL-C), have been shown in a meta-analysis of randomized trials to slow cIMT growth or even reduce cIMT. However, most research into cIMT has been conducted in European ancestry individuals, and little is known about whether the same causal risk factors apply for African ancestry populations.
Medical Research Council (MC_UU_00002/7)
National Institute for Health and Care Research (IS-BRC-1215-20014)
Wellcome Trust (204623/Z/16/Z)