Genetically Predicted Lipid Traits, Diabetes Liability, and Carotid Intima-Media Thickness in African Ancestry Individuals: A Mendelian Randomization Study.


Type
Article
Change log
Authors
Soremekun, Opeyemi 
Romuald Boua, Palwende  ORCID logo  https://orcid.org/0000-0001-8325-2665
Abstract

Carotid intima-media thickness (cIMT) is a measure of atherosclerosis used to predict cardiovascular disease.1 Lipid traits and type 2 diabetes (T2D) have been implicated in the pathogenesis of cIMT. Statins, which reduce low-density lipoprotein cholesterol (LDL-C), have been shown in a meta-analysis of randomized trials to slow cIMT growth or even reduce cIMT. However, most research into cIMT has been conducted in European ancestry individuals, and little is known about whether the same causal risk factors apply for African ancestry populations.

Description
Keywords
Mendelian randomization, ancestry, cardiovascular disease, carotid intima-media thickness, diabetes, ethnicity, lipids, Humans, Carotid Intima-Media Thickness, Mendelian Randomization Analysis, Risk Factors, Lipids, African People, Diabetes Mellitus
Journal Title
Circ Genom Precis Med
Conference Name
Journal ISSN
2574-8300
2574-8300
Volume Title
15
Publisher
Ovid Technologies (Wolters Kluwer Health)
Sponsorship
Wellcome Trust (100114/Z/12/Z)
Medical Research Council (MC_UU_00002/7)
National Institute for Health and Care Research (IS-BRC-1215-20014)
Wellcome Trust (204623/Z/16/Z)