Blood groups and the rise of human genetics in mid-twentieth century Britain
Repository URI
Repository DOI
Type
Change log
Authors
Abstract
This dissertation reconstructs how blood groups were made into pre-eminent objects of human genetic research and powerful markers for producing human biological difference. By tracing the ways in which three British laboratories became international centres for blood-group genetic research, it also offers an expanded history of postwar human genetics. In early 1930s Britain a community of geneticists, including R.A. Fisher andj.B.S. Haldane, promoted blood groups as having the potential to give the study of human heredity 'a solidly objective foundation, under strict statistical control'. Fisher and colleagues at the Cambridge Galton Serum Unit- especially Robert Race and Arthur Mourant- implemented this vision, the dissertation shows, using the arrangements for large-scale blood transfusion set up early in the Second World War. In 1946, Mourant became director of the Blood Group Reference Laboratory and Race of the Blood Group Research Unit, both at London's Lister Institute. As well as standardising blood-grouping reagents and investigating serological problems for the World Health Organization, these laboratories collected, analysed and published vast quantities of genetic data, making the Lister the global centre for blood-group genetics. During this period, human genetics changed from a marginal research field to an established discipline, partly, the dissertation argues, as a result of this blood-group research. By the 1950s a third of all human genetics publications were on blood groups: as one of the few human traits with simple Mendelian inheritance, they formed the basis for linkage studies and association surveys, and underpinned innovation in theoretical population genetics. Against a backdrop of intense international discussion about the meaning and scope of race science, blood groups were also made into tools for a supposedly 'obj ective' and 'unprejudiced' anthropology. This first history of how blood groups became scientific objects follows their collection in Britain and overseas, the grouping of samples, their transformation into data, and their presentation as credible genetic knowledge. It also offers the first sustained analysis of the functions of genetic nomenclatures. I argue that mid-century human genetics was profoundly influenced by the questions and practices of physical anthropology, by clinical practice, and by international infrastructures for medical research.
Description
This thesis is not available on this repository until the author agrees to make it public. If you are the author of this thesis and would like to make your work openly available, please contact us: thesis@repository.cam.ac.uk.
Cambridge University Library can make a copy of this work available only for the purposes of private study and non-commercial research. Copies should not be shared or saved in any shared facilities. Copyright over the content of these works is with their authors. Theses from the Library collection are considered unpublished works and according to UK legislation quoting from them is not allowed without permission from their author.
If you can commit to these terms, please complete the request form which you can find through this link: https://imagingservices.lib.cam.ac.uk/
Please note that print copies of theses may be available for consultation in the Cambridge University Library's Manuscript reading room. Admission details are at http://www.lib.cam.ac.uk/collections/departments/manuscripts-university-archives