Joining and splitting models with Markov melding.

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Goudie, Robert JB 
Presanis, Anne M 
Lunn, David 
De Angelis, Daniela  ORCID logo
Wernisch, Lorenz 

Analysing multiple evidence sources is often feasible only via a modular approach, with separate submodels specified for smaller components of the available evidence. Here we introduce a generic framework that enables fully Bayesian analysis in this setting. We propose a generic method for forming a suitable joint model when joining submodels, and a convenient computational algorithm for fitting this joint model in stages, rather than as a single, monolithic model. The approach also enables splitting of large joint models into smaller submodels, allowing inference for the original joint model to be conducted via our multi-stage algorithm. We motivate and demonstrate our approach through two examples: joining components of an evidence synthesis of A/H1N1 influenza, and splitting a large ecology model.

Bayesian melding, Markov combination, evidence synthesis, model integration
Journal Title
Bayesian Anal
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Institute of Mathematical Statistics
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