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Breaking the loop in AML.

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Peer-reviewed

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Article

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Abstract

In this issue of Blood1, Bamezai et al reveal an unexpected, moonlighting* function of the germ cell associated RNA binding protein, PIWIL4 in AML. The authors show a tumor-specific requirement for PIWIL4 in R-loop homeostasis. Loss of PIWIL4 in AML cells led to uncontrolled R-loop formation, transcriptional stalling, DNA damage and an enhanced sensitivity to ATR inhibition, findings that may inform future therapeutic approaches.

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Journal Title

Blood

Conference Name

Journal ISSN

0006-4971
1528-0020

Volume Title

Publisher

American Society of Hematology

Version History

Now showing 1 - 2 of 2
VersionDateSummary
2023-07-17 13:38:35
Published version added
1*
2023-05-24 00:30:14
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