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Therapeutic Potential of Astrocyte Transplantation.

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cam.issuedOnline2022-06-30
dc.contributor.authorHastings, Nataly
dc.contributor.authorKuan, Wei-Li
dc.contributor.authorOsborne, Andrew
dc.contributor.authorKotter, Mark
dc.contributor.orcidHastings, Nataly [0000-0002-5376-339X]
dc.contributor.orcidKotter, Mark [0000-0001-5145-7199]
dc.date.accessioned2022-07-01T15:00:21Z
dc.date.available2022-07-01T15:00:21Z
dc.date.issued2022-01
dc.date.submitted2022-01-27
dc.date.updated2022-07-01T15:00:20Z
dc.description.abstractCell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light recently as a therapy for amyotrophic lateral sclerosis (ALS); moreover, grafting of astrocytes also showed positive results in models of other conditions ranging from neurodegenerative diseases of older age to traumatic injury and stroke. Despite clear differences in etiology, disorders such as ALS, Parkinson's, Alzheimer's, and Huntington's diseases, as well as traumatic injury and stroke, converge on a number of underlying astrocytic abnormalities, which include inflammatory changes, mitochondrial damage, calcium signaling disturbance, hemichannel opening, and loss of glutamate transporters. In this review, we examine these convergent pathways leading to astrocyte dysfunction, and explore the existing evidence for a therapeutic potential of transplantation of healthy astrocytes in various models. Existing literature presents a wide variety of methods to generate astrocytes, or relevant precursor cells, for subsequent transplantation, while described outcomes of this type of treatment also differ between studies. We take technical differences between methodologies into account to understand the variability of therapeutic benefits, or lack thereof, at a deeper level. We conclude by discussing some key requirements of an astrocyte graft that would be most suitable for clinical applications.
dc.identifier.citationCell Transplantation, volume 31, article-number 09636897221105499
dc.identifier.doi10.17863/CAM.86071
dc.identifier.eissn1555-3892
dc.identifier.issn0963-6897
dc.identifier.other10.1177_09636897221105499
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338660
dc.languageen
dc.publisherSAGE Publications
dc.subjectBasic Research and Clinical Application of Cell Transplantation - Review (unsolicited)
dc.subjectastrocyte
dc.subjecttransplantation
dc.subjectneurodegeneration
dc.subjectinjury
dc.subjectbrain
dc.subjectspinal cord
dc.titleTherapeutic Potential of Astrocyte Transplantation.
dc.typeArticle
dcterms.dateAccepted2022-05-20
prism.publicationNameCell Transplant
pubs.funder-project-idMedical Research Council (MR/S005528/1)
rioxxterms.freetoread.startdate2022-06-30
rioxxterms.licenseref.startdate2022-06-30
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1177/09636897221105499

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