Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events.

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Wendt, Frank R 
Warrier, Varun 
Pathak, Gita A 
Koenen, Karestan C 
Stein, Murray B 

Background: Posttraumatic stress disorder (PTSD) is triggered by environmental stressors. Empathy may predispose an individual to respond to life events differently if high empathizers are emotionally more sensitive to trauma. For the first time, we test this hypothesis using genetic information. Methods: We applied polygenic scoring (PGS) to investigate the shared genetics linking empathy (measured using the Empathy Quotient (EQ), a self-report measure of empathy; N = 46,861) and PTSD symptom severity (measured using the 6-item PTSD Checklist 6-item (PCL-6)) in the UK Biobank (N = 126,219). Follow-up analyses were performed in the context of (1) experiencing any of 16 potential traumas, (2) the total number of traumas endorsed, and (3) the context of trauma. Autism, depression, generalized anxiety, and PCL-17 PGS were included as covariates to verify the specificity of the effect. Results: EQPGS associated with PCL-6 (R 2  = 0.012%, P = 9.35 × 10-5). This effect remained significant after accounting for autism, depression, PTSD, and anxiety PGS but was observed only in those who endorsed experiencing at least one traumatic event. EQPGS showed the strongest effect on PCL-6 (β = 2.32, s.e. = 0.762, P = 0.002) among those who endorsed childhood neglect/abuse (felt hated as a child). With respect to case status, the highest probability of PTSD was 17.93% and 10.04% for those who endorsed "feeling hated as a child" and those who did not, respectively (P diff = 0.011; Cohen's d = 1.951, 95%CI 1.70-2.20). Conclusions: A genetic predisposition to higher empathy, which may index greater emotional sensitivity, predisposes an individual to more severe PTSD symptoms, especially after early-life adversity.

Autism spectrum disorder, Empathizing, Pleiotropy, Polygenic score, Posttraumatic stress disorder, Trauma
Journal Title
Neurobiol Stress
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Elsevier BV