The low distance, $z=0.0591$, of GRB 100316D and its association with SN 2010bh represent two important motivations for studying this host galaxy and the GRB's immediate environment with the Integral-Field Spectrographs like VLT/MUSE. Its large field-of-view allows us to create 2D maps of gas metallicity, ionization level, and the star-formation rate distribution maps, as well as to investigate the presence of possible host companions. The host is a late-type dwarf irregular galaxy with multiple star-forming regions and an extended central region with signatures of on-going shock interactions. The GRB site is characterized by the lowest metallicity, the highest star-formation rate and the youngest ($\sim$ 20-30 Myr) stellar population in the galaxy, which suggest a GRB progenitor stellar population with masses up to 20 -- 40 $M\odot$. We note that the GRB site has an offset of $\sim$660pcfromthemostluminousSFregioninthehost.TheobservedSFactivityinthisgalaxymayhavebeentriggeredbyarelativelyrecentgravitationalencounterbetweenthehostandasmallundetected($L_{H\alpha} \leq 10^{36}$ erg/s) companion.