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The NEMP family supports metazoan fertility and nuclear envelope stiffness.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Pearson, Joel D 
Boswell, Curtis 

Abstract

Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish, and mice leads to sterility or early loss of fertility. Loss of Nemp leads to nuclear shaping defects, most prominently in the germ line. Biochemical, biophysical, and genetic studies reveal that NEMP proteins support the mechanical stiffness of the germline nuclear envelope via formation of a NEMP-EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties and that NEMP proteins play essential and conserved roles in fertility.

Description

Keywords

3101 Biochemistry and Cell Biology, 3105 Genetics, 31 Biological Sciences, Human Genome, Genetics, Contraception/Reproduction, Infertility, 1 Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance

Journal Title

Sci Adv

Conference Name

Journal ISSN

2375-2548
2375-2548

Volume Title

6

Publisher

American Association for the Advancement of Science (AAAS)
Sponsorship
Medical Research Council (MC_UU_12015/2)
MRC (MC_UU_00006/2)