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2021 DORIS definition of remission in SLE: final recommendations from an international task force.

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cam.issuedOnline2021-11-24
dc.contributor.authorvan Vollenhoven, Ronald F
dc.contributor.authorBertsias, George
dc.contributor.authorDoria, Andrea
dc.contributor.authorIsenberg, David
dc.contributor.authorMorand, Eric
dc.contributor.authorPetri, Michelle A
dc.contributor.authorPons-Estel, Bernardo A
dc.contributor.authorRahman, Anisur
dc.contributor.authorUgarte-Gil, Manuel Francisco
dc.contributor.authorVoskuyl, Alexandre
dc.contributor.authorArnaud, Laurent
dc.contributor.authorBruce, Ian N
dc.contributor.authorCervera, Ricard
dc.contributor.authorCostedoat-Chalumeau, Nathalie
dc.contributor.authorGordon, Caroline
dc.contributor.authorHoussiau, Frédéric A
dc.contributor.authorMosca, Marta
dc.contributor.authorSchneider, Matthias
dc.contributor.authorWard, Michael M
dc.contributor.authorAlarcon, Graciela
dc.contributor.authorAringer, Martin
dc.contributor.authorAskenase, Anka
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorBootsma, Hendrika
dc.contributor.authorBoumpas, Dimitrios T
dc.contributor.authorBrunner, Hermine
dc.contributor.authorClarke, Ann Elaine
dc.contributor.authorConey, Cindy
dc.contributor.authorCzirják, László
dc.contributor.authorDörner, Thomas
dc.contributor.authorFaria, Raquel
dc.contributor.authorFischer, Rebecca
dc.contributor.authorFritsch-Stork, Ruth
dc.contributor.authorInanc, Murat
dc.contributor.authorJacobsen, Søren
dc.contributor.authorJayne, David
dc.contributor.authorKuhn, Annegret
dc.contributor.authorvan Leeuw, Bernadette
dc.contributor.authorLimper, Maarten
dc.contributor.authorMariette, Xavier
dc.contributor.authorNavarra, Sandra
dc.contributor.authorNikpour, Mandana
dc.contributor.authorOlesinska, Marzena Helena
dc.contributor.authorPons-Estel, Guillermo
dc.contributor.authorRomero-Diaz, Juanita
dc.contributor.authorRubio, Blanca
dc.contributor.authorSchoenfeld, Yehuda
dc.contributor.authorBonfá, Eloisa
dc.contributor.authorSmolen, Josef
dc.contributor.authorTeng, YK Onno
dc.contributor.authorTincani, Angela
dc.contributor.authorTsang-A-Sjoe, Michel
dc.contributor.authorVasconcelos, Carlos
dc.contributor.authorVoss, Anne
dc.contributor.authorWerth, Victoria P
dc.contributor.authorZakharhova, Elena
dc.contributor.authorAranow, Cynthia
dc.contributor.orcidvan Vollenhoven, Ronald F [0000-0001-6438-8663]
dc.contributor.orcidDoria, Andrea [0000-0003-0548-4983]
dc.contributor.orcidMorand, Eric [0000-0002-9507-3338]
dc.contributor.orcidPetri, Michelle A [0000-0003-1441-5373]
dc.contributor.orcidPons-Estel, Bernardo A [0000-0003-2518-0266]
dc.contributor.orcidUgarte-Gil, Manuel Francisco [0000-0003-1728-1999]
dc.contributor.orcidArnaud, Laurent [0000-0002-8077-8394]
dc.contributor.orcidBruce, Ian N [0000-0003-3047-500X]
dc.contributor.orcidHoussiau, Frédéric A [0000-0003-1451-083X]
dc.contributor.orcidAringer, Martin [0000-0003-4471-8375]
dc.contributor.orcidBae, Sang-Cheol [0000-0003-4658-1093]
dc.contributor.orcidBoumpas, Dimitrios T [0000-0002-9812-4671]
dc.contributor.orcidBrunner, Hermine [0000-0001-9478-2987]
dc.contributor.orcidDörner, Thomas [0000-0002-6478-7725]
dc.contributor.orcidJacobsen, Søren [0000-0002-5654-4993]
dc.contributor.orcidTeng, YK Onno [0000-0001-9920-2195]
dc.contributor.orcidTsang-A-Sjoe, Michel [0000-0002-4982-3505]
dc.contributor.orcidWerth, Victoria P [0000-0003-3030-5369]
dc.contributor.orcidAranow, Cynthia [0000-0001-9299-0053]
dc.date.accessioned2022-02-14T14:00:34Z
dc.date.available2022-02-14T14:00:34Z
dc.date.issued2021-11
dc.date.submitted2021-07-12
dc.date.updated2022-02-14T14:00:33Z
dc.description.abstractOBJECTIVE: To achieve consensus on a definition of remission in SLE (DORIS). BACKGROUND: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. METHODS: Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on. RESULTS: Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator's Global Assessment <0.5 (0-3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics. CONCLUSION: The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.
dc.identifier.doi10.17863/CAM.81413
dc.identifier.eissn2053-8790
dc.identifier.issn2053-8790
dc.identifier.otherlupus-2021-000538
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334001
dc.languageen
dc.language.isoeng
dc.publisherBMJ
dc.publisher.urlhttp://dx.doi.org/10.1136/lupus-2021-000538
dc.subjecthealthcare
dc.subjectlupus erythematosus
dc.subjectoutcome assessment
dc.subjectsystemic
dc.subjecttherapeutics
dc.subjectHumans
dc.subjectImmunosuppressive Agents
dc.subjectLupus Erythematosus, Systemic
dc.subjectPrednisolone
dc.subjectRemission Induction
dc.subjectSeverity of Illness Index
dc.title2021 DORIS definition of remission in SLE: final recommendations from an international task force.
dc.typeArticle
dcterms.dateAccepted2021-11-04
prism.issueIdentifier1
prism.publicationNameLupus Sci Med
prism.volume8
pubs.funder-project-idUCB Pharma (n/a)
pubs.funder-project-idGlaxoSmithKline (n/a)
rioxxterms.freetoread.startdate2021-11-23
rioxxterms.licenseref.startdate2021-11-23
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1136/lupus-2021-000538

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