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Membrane extraction by calmodulin underpins the disparate signalling of RalA and RalB.

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cam.depositDate2022-03-10
cam.issuedOnline2022-03-23
cam.orpheus.counter2
cam.orpheus.successTue Apr 12 08:22:44 BST 2022 - Embargo updated
dc.contributor.authorChamberlain, Samuel G
dc.contributor.authorOwen, Darerca
dc.contributor.authorMott, Helen R
dc.contributor.orcidOwen, Darerca [0000-0003-0978-5425]
dc.contributor.orcidMott, Helen [0000-0002-7890-7097]
dc.date.accessioned2022-03-12T00:30:23Z
dc.date.available2022-03-12T00:30:23Z
dc.date.issued2022-06
dc.date.updated2022-03-10T19:04:42Z
dc.description.abstractBoth RalA and RalB interact with the ubiquitous calcium sensor, calmodulin (CaM). New structural and biophysical characterisation of these interactions strongly suggests that, in the native membrane-associated state, only RalA can be extracted from the membrane by CaM and this non-canonical interaction could underpin the divergent signalling roles of these closely related GTPases. The isoform specificity for RalA exhibited by CaM is hypothesised to contribute to the disparate signalling roles of RalA and RalB in mitochondrial dynamics. This would lead to CaM shuttling RalA to the mitochondrial membrane but leaving RalB localisation unperturbed, and in doing so triggering mitochondrial fission pathways rather than mitophagy.
dc.identifier.doi10.17863/CAM.82347
dc.identifier.eissn1521-1878
dc.identifier.issn0265-9247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334909
dc.language.isoeng
dc.publisherWiley
dc.publisher.departmentDepartment of Biochemistry
dc.publisher.urlhttp://dx.doi.org/10.1002/bies.202200011
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjectRalA
dc.subjectRalB
dc.subjectcalmodulin
dc.subjectisoprenylation
dc.subjectmembrane binding
dc.subjectmitochondria
dc.subjectsmall GTPase
dc.subjectCalmodulin
dc.subjectGTP Phosphohydrolases
dc.subjectProtein Isoforms
dc.subjectSignal Transduction
dc.titleMembrane extraction by calmodulin underpins the disparate signalling of RalA and RalB.
dc.typeArticle
dcterms.dateAccepted2022-03-10
prism.publicationNameBioessays
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/E013228/1)
pubs.funder-project-idBBSRC (BB/P504835/1)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1002/bies.202200011

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